Stephen M. Rappaport PhD

Emeritus Professor in Environmental Health Sciences
Director, Berkeley Center for Exposure Biology
  • PhD - Air & Industrial Hygiene, University of North Carolina,
    Chapel Hill, 1974
  • MSPH - Air & Industrial Hygiene, University of North Carolina,
    Chapel Hill, 1973
  • BS - Chemistry, University of Illinois, 1969
  • PH 150B: Introduction to Environmental Health Sciences
Research Interests: 
  • Development and application of biomarkers of exposure to toxic chemicals, including benzene and polycyclic aromatic hydrocarbons
  • Assessment of long-term chemical exposures for purposes of controlling workplace hazards and investigating exposure-response relationships
Current Projects: 

Professor Rappaport is Director and Principal Investigator of the Berkeley Center for Exposure Biology, a multidisciplinary program that brings together Berkeley researchers from Public Health, Chemistry, and Electrical Engineering to develop a new generation of biomarkers and biosensors for environmental epidemiology. He is a pioneer in the emerging field of ‘Exposure Biology’ and a prominent advocate of the concept of the ‘Exposome’ as a new paradigm for environmental health.  Much of his current research involves the development and application of blood protein adducts as biomarkers of exposure to toxic chemicals arising from inhalation, ingestion, and endogenous processes.  This has led to the concept of the protein adductome, representing signatures of people’s exposures to toxic chemicals.  By comparing adductomes across populations, Prof. Rappaport hopes to identify important biomarkers of chronic diseases.  He has also used environmental measurements and biomarkers to elucidate the human metabolism of several toxic chemicals, notably benzene, and to quantify interindividual variability in biomarker levels due to genetic, environmental and lifestyle factors. Prof. Rappaport has also published extensively in areas related to the assessment of long-term chemical exposures for purposes of controlling hazards and of investigating exposure-response relationships. He has more than 200 peer-reviewed publications and has collaborated extensively with investigators throughout the world.

Selected Publications: 

S.M. Rappaport, H. Li, H. Grigoryan, W.E. Funk, and E.R. Williams, Adductomics: Characterizing Exposures to Reactive Electrophiles, Toxicol Letters, in press.

H. Li, H. Grigoryan, W. E. Funk, S. S. Lu, S. Rose, E. R. Williams, and S.M. Rappaport, Profiling Cys34 Adducts of Human Serum Albumin by Fixed-Step Selected Reaction Monitoring, Mol Cell Proteomics, in press.

T. Whitehead, C. Metayer, P. Buffler, and S.M. Rappaport, Estimating Exposures to Indoor Contaminants using Residential Dust, J Exposure Sci Environ Epidemiol, in press.

S. Liu, S. K. Hammond, and S.M. Rappaport, Statistical Modeling to Determine Sources of Variability in Exposures to Welding Fumes, Ann Occup Hyg, 55(3):305-18 (2011).

S.M. Rappaport, Implications of the Exposome for Exposure Science, J Exposure Sci Environ Epidemiol, 21: 5-9 (2011).

S.M. Rappaport and M. T. Smith, Environment and Disease Risks, Science, 330: 460-461, 2010.

S.M. Rappaport, S. Kim, Q. Lan, G. Li, R. Vermeulen, S. Waidyanatha, L. Zhang, S. Yin, M. T. Smith, and N. Rothman, Human Benzene Metabolism Following Occupational and Environmental Exposures, Chemico-Biol Interact, 184: 189-195 (2010).

M. K. Chung, J. Riby, H. Li, A. T. Iavarone, E. R. Williams, Y. Zheng, and S.M. Rappaport, A Sandwich ELISA for Adducts of Polycyclic Aromatic Hydrocarbons with Human Serum Albumin, Analyt Biochem, 400: 123-129 (2010).

W. E. Funk, H. Li, A. T. Iavarone, E. R. Williams, J. Riby, and S.M. Rappaport, Enrichment of Cysteinyl Adducts of Human Serum Albumin, Analyt Biochem, 400: 61-68 (2010).

S. Fustinoni, P. Manini, L. Campo, G. De Palma, R. Andreoli, A. Mutti, P. A. Bertazzi, and S.M. Rappaport, Assessing Variability and Comparing Short-term Biomarkers of Styrene Exposure Using a Repeated Measurements Approach,Toxicol Lett, 142(1): 40-44 (2010).

T. Whitehead, R. B. Gunier, M. H. Ward, M. G. Nishioka, C. Metayer, P. Buffler, and S.M. Rappaport, Determinants of Polycyclic Aromatic Hydrocarbon Levels in House Dust, J Exposure Sci Environ Epidemiol,169: 1113-1123 (2009).

Profile Updated: November 15, 2018