Sangwei Lu PhD

Adjunct Professor, Infectious Diseases
  • PhD – Biology, Yale University
  • BS – Molecular Biology, University of Science and Technology of China
  • PH266A: Foodborne Diseases (Spring 2019, 2021)
Research Interests: 
  • Pathogenesis and transmission of Salmonella
  • Foodborne diseases - detection and prevention 
  • Child-friendly formulations of antibiotics 
Research Description: 

The research in our laboratory focuses on foodborne pathogens, especially Salmonella serovars. We study how Salmonella regulates its virulence characteristics and how it colonizes animal hosts. We also develop attenuated Salmonella strains for use as gene-delivery tools. More recently we have been developing child-friendly formulations of antibiotics to make life-saving medicines available to all children in need.

Selected Publications: 

Mempin, R., Tran, H., Chen, C., Gong, H., Ho, K. K, and Lu, S. (2013)  Release of extracellular ATP by bacteria during growth. BMC Microbiol. 13, 301. Pubmed

Liu, Y., Ho, K. K., Su, J., Gong, H., Chang, A. C., and Lu, S. (2013) Potassium transport of Salmonella is important for type III secretion and pathogenesis. Microbiology 159, 1705-19. Pubmed

Jiang, X., Gong, H., Chen, Y. C., Vu, G. P., Trang, P., Zhang, C. Y., Lu, S., and Liu F. (2012) Effective inhibition of cytomegalovirus infection by external guide sequences in mice. Proc. Natl. Acad. Sci. USA. 109, 13070-5. Pubmed

Bai, Y., Gong, H., Li, H., Vu, G., Lu, S., and Liu, F. (2011). Oral delivery of RNase P ribozymes by Salmonella effectively inhibits viral infection in mice. Proc. Natl. Acad. Sci. USA. 108, 3222-3227. Pubmed

Bai, Y., Li, H., Vu, G., Gong, H., Umamoto, S., Zhou, T., Lu, S. and Liu, F (2010) Salmonella-mediated delivery of RNase P-based ribozymes for inhibition of viral gene expression and replication in human cells. Proc. Natl. Acad. Sci. U. S. A. 107, 7269-7274. Pubmed

Loui, C., Chang, A. C. and Lu, S. (2009) Role of the ArcAB Two-Component System in the Resistance of Escherichia coli to Reactive Oxygen Stress. BMC Microbiology 9, 183. Pubmed

Gong, H., Su, J., Bai, Y., Miao, L., Kim, K., Yang, Y., Liu, F., and Lu, S. (2009) Characterization of the expression of Salmonella Type III secretion system factor PrgI, SipA, SipB, SopE2, SpaO, and SptP in cultures and in mice. BMC Microbiology. 9, 73. Pubmed

Su. J., Gong, H., Lai, J. T., Main, A. J. and Lu, S. (2009) Potassium transporter Trk and external potassium modulate Salmonella protein secretion and virulence. Infection and Immunity 77, 667-75. Pubmed

Loui, C., Grigoryan, G., Huang, H., Riley, L. W. and Lu, S. (2008) Bacterial communities associated with retail alfalfa sprouts. Journal of Food Protection 71, 200-204. Pubmed

Kang, H., Loui, C. S., Clavijo, R. I., Riley, L. W. and Lu, S (2006). Survival characteristics of Salmonella enterica serotype Enteritidis in chicken egg albumen. Epidemiology and Infection 134, 967-976. Pubmed

Clavijo, R. I., Loui, C. S., Andersen, G. L., Riley, L. W. and Lu, S. (2006) Identification of genes associated with the survival of Salmonella entericaserovar Enteritidis in chicken egg albumen. Appl Environ Microbiol. 72, 1055-1064. Pubmed

Lu, S., Killoran, P. B., and Riley, L. W. (2003) Association of Salmonella enterica serovar Enteritidis YafD with chicken egg albumen resistance. Infection and Immunity 71, 6734-6741. Pubmed

Lu, S., Killoran, P. B., Fang, F. C. and Riley, L. W. (2002) The global regulator ArcA controls resistance to reactive nitrogen and oxygen intermediates in Salmonella enteritidis. Infection and Immunity 70, 451-461. Pubmed

Profile Updated: August 18, 2018