Lisa F. Barcellos PhD, MPH

Professor of Epidemiology
Director, Center for Computational Biology
Co-director, Undergraduate Public Health Major Program
  • PB HLTH 150A: Introduction to Epidemiology and Human Disease
  • PB HLTH 256: Molecular and Genetic Epidemiology and Human Health in the 21st Century
Research Interests: 
  • Genetic epidemiology of complex diseases
  • Identification of genetic and environmental risk factors for multiple sclerosis
  • Genetic variation in the major histocompatibility complex (MHC) and autoimmune disease
  • Maternal-child histocompatibility and risk of autoimmune disease
  • Epigenetic contributions to autoimmune disease risk
  • Application of causal inference methods to autoimmune disease studies
Selected Publications: 

Bos SD, Page C, Andreassen BK, Elboudwarej E, Gustavsen MW, Briggs F, Quach H, Leikfoss IS, Bjgerud A, Berge T, Harbo HF, Barcellos LF. Genome-wide DNA methylation profiles indicate CD8+ T cell hypermethylation in multiple sclerosis. PLoS One, In press.

Chung SA, Nititham J, Elboudwarej E, Quach HL, Taylor KE, Barcellos LF*, Criswell LA*. Genome-wide assessment of differential methylation associated with autoantibody production in systemic lupus erythematosus. PLoS One, in Press (*Co-Senior authors).

Briggs FBS, Leung L, Barcellos LF. Annotation of functional variation within non-MHC MS susceptibility loci through bioinformatics analysis, Genes Immun. 2014, 15:466-76.

Gianfrancesco MA, Acu BS, Shen L, Briggs FBS, Quach H, Bellesis KH, Bernstein A, Hedstrom AK, Kockum I, Alfredsson L, Olsson T, Schaefer C, Barcellos LF. Obesity during childhood and adolescence increases susceptibility to multiple sclerosis after accounting for established genetic and environmental risk factors, Obesity Res & Clin Pract. 2014, 8(5):435-47.

Hedstrom AK, Lima I, Barcellos LF, Schaefer C, Briggs FBS, Kockum IS, Olsson T, Alfredsson L. Interaction between passive smoking and two HLA genes with regard to MS risk, International Journal of Epidemiology. In press.

Briggs FB, Acu BS, Shen L, Bellesis KH, Ramsay PP, Quach H, Bernstein A, Schaefer C, Barcellos LF. Adverse socioeconomic position during the life course is associated with multiple sclerosis. J Epidemiol Community Health. 2014, 68:622-9. PubMed PMID: 24577137.

Briggs FB, Acuna B, Shen L, Ramsay P, Quach H, Bernstein A, Bellesis KH, Kockum IS, Hedstr AK, Alfredsson L, Olsson T, Schaefer C, Barcellos LF. Smoking and Risk of Multiple Sclerosis: Evidence of Modification by NAT1 Variants. Epidemiology. 2014, 25:605-14. PubMed PMID: 24625537.

International Multiple Sclerosis Genetics Consortium; Wellcome Trust Case Control Consortium 2. Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature. 2011 Aug 10;476(7359):214-9. doi: 10.1038/nature10251. PubMed PMID: 21833088; PubMed Central PMCID: PMC3182531.

Bronson PG, Goldstein BA, Ramsay PP, Beckman KB, Noble JA, Lane JA, Seldin MF, Kelly JA, Harley JB, Moser KL, Gaffney PM, Behrens TW, Criswell LA, Barcellos LF. The rs4774 CIITA missense variant is associated with risk of systemic lupuserythematosus. Genes Immun. 2011 Dec;12(8):667-71. doi: 10.1038/gene.2011.36. Epub 2011 May 26. PubMed PMID: 21614020; PubMed Central PMCID: PMC3387803.

Bronson PG, Ramsay PP, Seldin MF, Gregersen PK, Criswell LA, Barcellos LF. CIITA is not associated with risk of developing rheumatoid arthritis. Genes Immun. 2011 Apr;12(3):235-8. Epub 2011 Jan 20. PubMed PMID: 21248776; PubMed Central PMCID: PMC3449225.

Briggs FB, Bartlett SE, Goldstein BA, Wang J, McCauley JL, Zuvich RL, De Jager PL, Rioux JD, Ivinson AJ, Compston A, Hafler DA, Hauser SL, Oksenberg JR, Sawcer SJ, Pericak-Vance MA, Haines JL; International Multiple Sclerosis Genetics Consortium, Barcellos LF. Evidence for CRHR1 in multiple sclerosis using supervised machine learning and meta-analysis in 12,566 individuals. Hum Mol Genet. 2010 Nov 1;19(21):4286-95. Epub 2010 Aug 10. PubMed PMID: 20699326; PubMed Central PMCID: PMC2951862.

Goldstein BA, Hubbard AE, Cutler A, Barcellos LF. BMC Genet. 2010 Jun 14;11:49. PubMed PMID: 20546594; PubMed Central PMCID: PMC2896336.

Briggs FB, Goldstein BA, McCauley JL, Zuvich RL, De Jager PL, Rioux JD, Ivinson AJ, Compston A, Hafler DA, Hauser SL, Oksenberg JR, Sawcer SJ, Pericak-Vance MA, Haines JL, Barcellos LF; International Multiple Sclerosis Genetics Consortium. Variation within DNA repair pathway genes and risk of multiple sclerosis. Am J Epidemiol. 2010 Jul 15;172(2):217-24. Epub 2010 Jun 3. PubMed PMID: 20522537.

Bronson PG, Ramsay PP, Seldin MF, Gregersen PK, Criswell LA, Barcellos LF. A candidate gene study of CLEC16A does not provide evidence of association with risk for anti-CCP-positive rheumatoid arthritis. Genes Immun. 2010 Sep;11(6):504-8. Epub 2010 Mar 11. PubMed PMID: 20220768; PubMed Central PMCID: PMC2992879.

Bronson PG, Caillier S, Ramsay PP, McCauley JL, Zuvich RL, De Jager PL, Rioux  JD, Ivinson AJ, Compston A, Hafler DA, Sawcer SJ, Pericak-Vance MA, Haines JL; International Multiple Sclerosis Genetics Consortium, Hauser SL, Oksenberg JR, Barcellos LF. CIITA variation in the presence of HLA-DRB1*1501 increases risk for multiple sclerosis. Hum Mol Genet. 2010 Jun 1;19(11):2331-40. Epub 2010 Mar 8. PubMed PMID: 20211854; PubMed Central PMCID: PMC2865376.

Bronson PG, Komorowski LK, Ramsay PP, May SL, Noble J, Lane JA, Thomson G, Claas FH, Seldin MF, Kelly JA, Harley JB, Moser KL, Gaffney PM, Behrens T, Criswell LA, Barcellos LF. Analysis of maternal-offspring HLA compatibility, parent-of-origin effects, and noninherited maternal antigen effects for HLA-DRB1 in systemic lupus erythematosus. Arthritis Rheum. 2010 Jun;62(6):1712-7. PubMed PMID: 20191587; PubMed Central PMCID: PMC2948464.

Briggs FB, Ramsay PP, Madden E, Norris JM, Holers VM, Mikuls TR, Sokka T, Seldin MF, Gregersen PK, Criswell LA, Barcellos LF. Supervised machine learning and logistic regression identifies novel epistatic risk factors with PTPN22 for rheumatoid arthritis. Genes Immun. 2010 Apr;11(3):199-208. Epub 2010 Jan 21. PubMed PMID: 20090771; PubMed Central PMCID: PMC3118040.

Valdes AM, Thomson G, Barcellos LF. Genetic variation within the HLA class III influences T1D susceptibility conferred by high-risk HLA haplotypes. Genes Immun. 2010 Apr;11(3):209-18. Epub 2010 Jan 7. PubMed PMID: 20054343; PubMed Central PMCID: PMC2858242.

Barcellos LF, May SL, Ramsay PP, Quach HL, Lane JA, Nititham J, Noble JA, Taylor KE, Quach DL, Chung SA, Kelly JA, Moser KL, Behrens TW, Seldin MF, Thomson G, Harley JB, Gaffney PM, Criswell LA. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. PLoS Genet. 2009 Oct;5(10):e1000696. Epub 2009 Oct 23. PubMed PMID: 19851445; PubMed Central PMCID: PMC2758598.

Bronson PG, Ramsay PP, Thomson G, Barcellos LF; Diabetes Genetics Consortium. Analysis of maternal-offspring HLA compatibility, parent-of-origin and non-inherited maternal effects for the classical HLA loci in type 1 diabetes. Diabetes Obes Metab. 2009 Feb;11 Suppl 1:74-83. PubMed PMID: 19143818; PubMed Central PMCID: PMC2635943.

Other interests: 
  • Core Faculty Member - Computational Biology Graduate Group
  • Director - QB3 Genetic Epidemiology and Genomics Laboratory
  • Adjunct Researcher - Kaiser Permanente Division of Research
  • Kaiser Permanente Research Program on Genes, Environment and Health
  • Founding Member - International Multiple Sclerosis Genetics Consortium
  • Member - NIH Genetics of Health and Disease (GHD) Study Section
  • Member - American Society of Human Genetics
  • Member - Committee for Protection of Human Subjects
  • Affiliate Member - QB3
  • Fellow - Institute of Medicine Anniversary
Profile Updated: August 15, 2016