Lisa F. Barcellos PhD, MPH

Professor of Epidemiology
Director, Center for Computational Biology
Director, Undergraduate Public Health Major Program
Courses: 
  • PB HLTH 150A: Introduction to Epidemiology and Human Disease (Spring, 4.0 units)
  • PB HLTH 256: Human Genome, Environment and Public Health (Spring, 4.0 units)
  • PB HLTH 196: Capstone Research Seminar for Undergraduates (Fall, 3.0 units)
Research Interests: 
  • Genetic epidemiology of complex diseases
  • Identification of genetic and environmental risk factors for multiple sclerosis
  • Genetic variation in the major histocompatibility complex (MHC) and autoimmune disease
  • Maternal-child histocompatibility and risk of autoimmune disease
  • Epigenetic contributions to autoimmune disease risk
  • Application of causal inference methods to autoimmune disease studies
Selected Publications: 
Mowry EM, Hedström AK, Gianfrancesco MA, Shao X, Schaefer CA, Shen L, Bellesis KH, Briggs FBS, Olsson T, Alfredsson L, Barcellos LF. Incorporating machine learning approaches to assess putative environmental risk factors for multiple sclerosis. Mult Scler Relat Disord. 2018 Jun 23;24:135-141. doi: 10.1016/j.msard.2018.06.009. [Epub ahead of print] PubMed PMID: 30005356.
  
Mok A, Rhead B, Holingue C, Shao X, Quach HL, Quach D, Sinclair E, Graf J, Imboden J, Link T, Harrison R, Chernitskiy V, Barcellos LF, Criswell LA. Hypomethylation of CYP2E1 and DUSP22 Promoters Associated With Disease Activity and Erosive Disease Among Rheumatoid Arthritis Patients. Arthritis Rheumatol. 2018 Apr;70(4):528-536. doi: 10.1002/art.40408. Epub 2018 Feb 18. PubMed PMID: 29287311; PubMed Central PMCID: PMC5876118.
 
Gianfrancesco MA, Stridh P, Shao X, Rhead B, Graves JS, Chitnis T, Waldman A,  Lotze T, Schreiner T, Belman A, Greenberg B, Weinstock-Guttman B, Aaen G, Tillema JM, Hart J, Caillier S, Ness J, Harris Y, Rubin J, Candee M, Krupp L, Gorman M, Benson L, Rodriguez M, Mar S, Kahn I, Rose J, Roalstad S, Casper TC, Shen L, Quach H, Quach D, Hillert J, Hedstrom A, Olsson T, Kockum I, Alfredsson L, Schaefer C, Barcellos LF, Waubant E; Network of Pediatric Multiple Sclerosis Centers. Genetic risk factors for pediatric-onset multiple sclerosis. Mult Scler. 2017 Oct 1:1352458517733551. doi: 10.1177/1352458517733551. [Epub ahead of print] PubMed PMID: 28980494; PubMed Central PMCID: PMC5878964.
 
Cruz GI, Shao X, Quach H, Ho KA, Sterba K, Noble JA, Patsopoulos NA, Busch MP, Triulzi DJ, Wong WS, Solomon BD, Niederhuber JE, Criswell LA, Barcellos LF. Increased risk of rheumatoid arthritis among mothers with children who carry DRB1 risk-associated alleles. Ann Rheum Dis. 2017 Aug;76(8):1405-1410. doi: 10.1136/annrheumdis-2016-210662. Epub 2017 Apr 8. PubMed PMID: 28391248.
 
Gianfrancesco MA, Stridh P, Rhead B, Shao X, Xu E, Graves JS, Chitnis T, Waldman A, Lotze T, Schreiner T, Belman A, Greenberg B, Weinstock-Guttman B, Aaen G, Tillema JM, Hart J, Caillier S, Ness J, Harris Y, Rubin J, Candee M, Krupp L, Gorman M, Benson L, Rodriguez M, Mar S, Kahn I, Rose J, Roalstad S, Casper TC, Shen L, Quach H, Quach D, Hillert J, Bäärnhielm M, Hedstrom A, Olsson T, Kockum I, Alfredsson L, Metayer C, Schaefer C, Barcellos LF, Waubant E; Network of Pediatric Multiple Sclerosis Centers. Evidence for a causal relationship between low vitamin D, high BMI, and pediatric-onset MS. Neurology. 2017 Apr 25;88(17):1623-1629. doi: 10.1212/WNL.0000000000003849. Epub 2017 Mar 29. PubMed PMID: 28356466; PubMed Central PMCID: PMC5405763.
 
Barcellos LF, Bellesis KH, Shen L, Shao X, Chinn T, Frndak S, Drake A, Bakshi N, Marcus J, Schaefer C, Benedict RH. Remote assessment of verbal memory in MS patients using the California Verbal Learning Test. Mult Scler. 2018 Mar;24(3):354-357. doi: 10.1177/1352458517694087. Epub 2017 Feb 1. PubMed PMID: 28273777; PubMed Central PMCID: PMC5538936.
 
Gianfrancesco MA, Glymour MM, Walter S, Rhead B, Shao X, Shen L, Quach H, Hubbard A, Jónsdóttir I, Stefánsson K, Strid P, Hillert J, Hedström A, Olsson T, Kockum I, Schaefer C, Alfredsson L, Barcellos LF. Causal Effect of Genetic Variants Associated With Body Mass Index on Multiple Sclerosis Susceptibility. Am J Epidemiol. 2017 Feb 1;185(3):162-171. doi: 10.1093/aje/kww120. PubMed PMID: 28073764; PubMed Central PMCID: PMC5391720.
 
Gianfrancesco MA, Barcellos LF. Obesity and Multiple Sclerosis Susceptibility: A Review. J Neurol Neuromedicine. 2016;1(7):1-5. PubMed PMID: 27990499; PubMed Central PMCID: PMC5156319.
 
Olsson T, Barcellos LF, Alfredsson L. Interactions between genetic, lifestyle and environmental risk factors for multiple sclerosis. Nat Rev Neurol. 2017 Jan;13(1):25-36. doi: 10.1038/nrneurol.2016.187. Epub 2016 Dec 9. Review. PubMed PMID: 27934854.
 
Cruz GI, Shao X, Quach H, Ho KA, Sterba K, Noble JA, Patsopoulos NA, Busch MP, Triulzi DJ, Wong WS, Solomon BD, Niederhuber JE, Criswell LA, Barcellos LF. A Child's HLA-DRB1 genotype increases maternal risk of systemic lupus erythematosus. J Autoimmun. 2016 Nov;74:201-207. doi: 10.1016/j.jaut.2016.06.017. Epub 2016 Jul 4. PubMed PMID: 27388144; PubMed Central PMCID: PMC5079818.
 
Rhead B, Holingue C, Cole M, Shao X, Quach HL, Quach D, Shah K, Sinclair E, Graf J, Link T, Harrison R, Rahmani E, Halperin E, Wang W, Firestein GS, Barcellos LF, Criswell LA. Rheumatoid Arthritis Naive T Cells Share Hypermethylation Sites With Synoviocytes. Arthritis Rheumatol. 2017 Mar;69(3):550-559. doi: 10.1002/art.39952. PubMed PMID: 27723282; PubMed Central PMCID: PMC5328845.
 
Rhead B, Bäärnhielm M, Gianfrancesco M, Mok A, Shao X, Quach H, Shen L, Schaefer C, Link J, Gyllenberg A, Hedström AK, Olsson T, Hillert J, Kockum I, Glymour MM, Alfredsson L, Barcellos LF. Mendelian randomization shows a causal effect of low vitamin D on multiple sclerosis risk. Neurol Genet. 2016 Sep 13;2(5):e97. doi: 10.1212/NXG.0000000000000097. eCollection 2016 Oct. PubMed PMID: 27652346; PubMed Central PMCID: PMC5022843.
 
George MF, Briggs FB, Shao X, Gianfrancesco MA, Kockum I, Harbo HF, Celius EG, Bos SD, Hedström A, Shen L, Bernstein A, Alfredsson L, Hillert J, Olsson T, Patsopoulos NA, De Jager PL, Oturai AB, Søndergaard HB, Sellebjerg F, Sorensen PS, Gomez R, Caillier SJ, Cree BA, Oksenberg JR, Hauser SL, D'Alfonso S, Leone MA, Martinelli Boneschi F, Sorosina M, van der Mei I, Taylor BV, Zhou Y, Schaefer C, Barcellos LF. Multiple sclerosis risk loci and disease severity in 7,125 individuals from 10 studies. Neurol Genet. 2016 Aug 4;2(4):e87. doi: 10.1212/NXG.0000000000000087. eCollection 2016 Aug. PubMed PMID: 27540591; PubMed Central PMCID: PMC4974846.
 
Gianfrancesco MA, Balzer L, Taylor KE, Trupin L, Nititham J, Seldin MF, Singer AW, Criswell LA, Barcellos LF. Genetic risk and longitudinal disease activity in systemic lupus erythematosus using targeted maximum likelihood estimation. Genes Immun. 2016 Sep;17(6):358-62. doi: 10.1038/gene.2016.33. Epub 2016 Jul 28. PubMed PMID: 27467283; PubMed Central PMCID: PMC5008986.
 
Cole MB, Quach H, Quach D, Baker A, Taylor KE, Barcellos LF, Criswell LA. Epigenetic Signatures of Salivary Gland Inflammation in Sjögren's Syndrome. Arthritis Rheumatol. 2016 Dec;68(12):2936-2944. doi: 10.1002/art.39792. PubMed PMID: 27332624; PubMed Central PMCID: PMC5132022.
 
16: Bos SD, Page CM, Andreassen BK, Elboudwarej E, Gustavsen MW, Briggs F, Quach H, Leikfoss IS, Bjølgerud A, Berge T, Harbo HF, Barcellos LF. Genome-wide DNA methylation profiles indicate CD8+ T cell hypermethylation in multiple sclerosis. PLoS One. 2015 Mar 3;10(3):e0117403. doi: 10.1371/journal.pone.0117403. eCollection 2015. PubMed PMID: 25734800; PubMed Central PMCID: PMC4348521.
 
Briggs FB, Leung LJ, Barcellos LF. Annotation of functional variation within non-MHC MS susceptibility loci through bioinformatics analysis. Genes Immun. 2014 Oct;15(7):466-76. doi: 10.1038/gene.2014.37. Epub 2014 Jul 17. PubMed PMID: 25030428.
 
Briggs FB, Acuna B, Shen L, Ramsay P, Quach H, Bernstein A, Bellesis KH, Kockum IS, Hedström AK, Alfredsson L, Olsson T, Schaefer C, Barcellos LF. Smoking and risk of multiple sclerosis: evidence of modification by NAT1 variants. Epidemiology. 2014 Jul;25(4):605-14. doi: 10.1097/EDE.0000000000000089. PubMed PMID: 24625537.
 
Patsopoulos NA, Barcellos LF, Hintzen RQ, Schaefer C, van Duijn CM, Noble JA, Raj T; IMSGC; ANZgene, Gourraud PA, Stranger BE, Oksenberg J, Olsson T, Taylor BV, Sawcer S, Hafler DA, Carrington M, De Jager PL, de Bakker PI. Fine-mapping the genetic association of the major histocompatibility complex in multiple sclerosis: HLA and non-HLA effects. PLoS Genet. 2013 Nov;9(11):e1003926. doi: 10.1371/journal.pgen.1003926. Epub 2013 Nov 21. PubMed PMID: 24278027; PubMed Central PMCID: PMC3836799.
 
International Multiple Sclerosis Genetics Consortium (IMSGC), Beecham AH, Patsopoulos NA, Xifara DK, Davis MF, Kemppinen A, Cotsapas C, Shah TS, Spencer C, Booth D, Goris A, Oturai A, Saarela J, Fontaine B, Hemmer B, Martin C, Zipp F, D'Alfonso S, Martinelli-Boneschi F, Taylor B, Harbo HF, Kockum I, Hillert J, Olsson T, Ban M, Oksenberg JR, Hintzen R, Barcellos LF; Wellcome Trust Case Control Consortium 2 (WTCCC2); International IBD Genetics Consortium (IIBDGC), Agliardi C, Alfredsson L, Alizadeh M, Anderson C, Andrews R, Søndergaard HB, Baker A, Band G, Baranzini SE, Barizzone N, Barrett J, Bellenguez C, Bergamaschi L, Bernardinelli L, Berthele A, Biberacher V, Binder TM, Blackburn H, Bomfim IL, Brambilla P, Broadley S, Brochet B, Brundin L, Buck D, Butzkueven H, Caillier SJ, Camu W, Carpentier W, Cavalla P, Celius EG, Coman I, Comi G, Corrado L, Cosemans L, Cournu-Rebeix I, Cree BA, Cusi D, Damotte V, Defer G, Delgado SR, Deloukas P, di Sapio A, Dilthey AT, Donnelly P, Dubois B, Duddy M, Edkins S, Elovaara I, Esposito F, Evangelou N, Fiddes B, Field J, Franke A, Freeman C, Frohlich IY, Galimberti D, Gieger C, Gourraud PA, Graetz C, Graham A, Grummel V, Guaschino C, Hadjixenofontos A, Hakonarson H, Halfpenny C, Hall G, Hall P, Hamsten A, Harley J, Harrower T, Hawkins C, Hellenthal G, Hillier C, Hobart J, Hoshi M, Hunt SE, Jagodic M, Jelčić I, Jochim A, Kendall B, Kermode A, Kilpatrick T, Koivisto K, Konidari I, Korn T, Kronsbein H, Langford C, Larsson M, Lathrop M, Lebrun-Frenay C, Lechner-Scott J, Lee MH, Leone MA, Leppä V, Liberatore G, Lie BA, Lill CM, Lindén M, Link J, Luessi F, Lycke J, Macciardi F, Männistö S, Manrique CP, Martin R, Martinelli V, Mason D, Mazibrada G, McCabe C, Mero IL, Mescheriakova J, Moutsianas L, Myhr KM, Nagels G, Nicholas R, Nilsson P, Piehl F, Pirinen M, Price SE, Quach H, Reunanen M, Robberecht W, Robertson NP, Rodegher M, Rog D, Salvetti M, Schnetz-Boutaud NC, Sellebjerg F, Selter RC, Schaefer C, Shaunak S, Shen L, Shields S, Siffrin V, Slee M, Sorensen PS, Sorosina M, Sospedra M, Spurkland A, Strange A, Sundqvist E, Thijs V, Thorpe J, Ticca A, Tienari P, van Duijn C, Visser EM, Vucic S, Westerlind H, Wiley JS, Wilkins A, Wilson JF, Winkelmann J, Zajicek J, Zindler E, Haines JL, Pericak-Vance MA, Ivinson AJ, Stewart G, Hafler D, Hauser SL, Compston A, McVean G, De Jager P, Sawcer SJ, McCauley JL. Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis. Nat Genet. 2013 Nov;45(11):1353-60. doi: 10.1038/ng.2770. Epub 2013 Sep 29. PubMed PMID: 24076602; PubMed Central PMCID: PMC3832895.
Other interests: 
  • Core Faculty Member - Computational Biology Graduate Group
  • Director - QB3 Genetic Epidemiology and Genomics Laboratory
  • Adjunct Researcher - Kaiser Permanente Division of Research
  • Founding Member - International Multiple Sclerosis Genetics Consortium
  • Member - American Society of Human Genetics
  • Member - Committee for Protection of Human Subjects
  • Member - Committee on Courses of Instruction
  • Affiliate Member - QB3
Profile Updated: October 8, 2018