Daniel Portnoy, Ph.D.
Professor of Molecular and Cell Biology
PHONE: (510) 643-3925
FAX: (510) 643-7038
LOCATION: 508 Barker Hall #3202
E-MAIL: portnoy@berkeley.edu
WEBSITE: The Portnoy Lab
Research Interests
- Intracellular Pathogens
- Listeria monocytogenes
- Cell Biology
- Innate immunity
- Vaccines
Publications
Sauer, J.D., S. Peryere, K.A. Archer, B. Hanson, P. Lauer, D.A. Portnoy. Listeria monocytogenes engineered to activate the Nlrc4 inflammasome are severely attenuated and fail to induce protective immunity. Proc. Natl. Acad. Sci. USA. (In Press, 2011)
Waite, J.C., I. Leiner, P. Lauer, H. Zheng, C.S. Rae, A.K. Chakraborty, D.A. Portnoy, E.G. Pamer, M.L. Dustin. Dynamic imaging of the effector immune response to Listeria infection in vivo. PLoS Pathog. Mar;7(3):e1001326. (2011)
Sauer J.D., K. Sotelo-Troha, J. von Moltke, K.M. Monroe, C.S. Rae, S.W. Brubaker, M. Hyodo, Y. Hayakawa, J.J. Woodward, D.A. Portnoy, R.E. Vance. The ENU-induced Goldenticket (Gt) mouse mutant reveals an essential function of Sting (Tmem173, Mita, Mpys, Eris) in the in vivo interferon response to Listeria monocytogenes and cyclic-di-nucleotides. Infect. Immun. 79(2):688-94. (2011)
Woodward, J.J., A.T. Iavarone, D.A. Portnoy. c-di-AMP secreted by intracellular Listeria monocytogenes activates a host type I interferon response. Science. 328:1703-1705. (2010)
Bahjat, K.S., N. Meyer-Morse, E.E. Lemmens, J.A. Shugart, T.W. Dubensky, Jr., D.G. Brockstedt, and D.A. Portnoy. Suppression of cell-mediated immunity following recognition of phagosome-confined bacteria. PLoS Pathog. 5(9):e1000568. (2009)
Vance, R.E., R.R. Isberg, and D.A. Portnoy. Patterns of pathogenesis: discrimination of pathogenic and nonpathogenic microbes by the innate immune system. Review. Cell Host & Microbe, Jul 23;6(1): 10-21. (2009).
Zemansky, J., B. Kline, J.J. Woodward, J.H. Leber, H. Marquis, and D.A. Portnoy. Development of a mariner-based transposon and identification of Listeria monocytogenes determinants, including the peptidyl-proline isomerase, PrsA2, that contribute to its hemolytic phenotype. J. Bacteriol. 191(12):3950-64. (2009)
Crimmins, G.T. A.A. Herskovits, K. Rehder, K.E. Sivickm T.W. Dubensky, Jr., and D.A. Portnoy. Listeria monocytogenes multidrug resistance transporters activate a cytosolic surveillance pathway of innate immunity. Proc. Natl. Acad. Sci. USA. 105(29):10191-6. (2008)Profile Updated: July 18, 2011