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Eva Harris, Ph.D.
Professor, Division of Infectious Diseases and Vaccinology
Director, Center for Global Public Health
PHONE: (510) 642-4845
FAX: (510) 642-6350
OFFICE: 500B Li Ka Shing Center
LAB: 510D Li Ka Shing Center
E-MAIL: eharris@berkeley.edu

Courses

Research Interests

Research Description

Dr. Harris has developed a multidisciplinary approach to study the molecular virology, pathogenesis, immunology, and epidemiology of dengue, the most prevalent mosquito-borne viral disease in humans. Her work investigates the mechanism of dengue virus translation and replication and host cell-virus interactions, as well as viral and host factors that modulate disease severity. One major research focus has been the development of a mouse model to study viral tropism and pathogenesis, investigate the immune response to dengue virus infection, and generate a better model of disease. This has resulted in a mouse model for antibody-dependent enhancement of dengue disease that is being used to dissect antibody determinants of protection, enhancement, and therapeutic efficacy and to test different classes of candidate antiviral compounds. Her field work focuses on laboratory-based and epidemiological studies of dengue and influenza in endemic Latin American countries.

Publications

Zompi Z, Montoya M, Pohl M, Balmaseda A, Harris E. Dominant cross-reactive B cell response during secondary acute dengue virus infection in humans. PLoS Negl Trop Dis. 2012. 6: e1568.

Zompi S, Santich BH, Beatty PR, Harris E. Protection from secondary dengue virus infection in a mouse model reveals the role of serotype cross-reactive B and T cells. J Immunol. 2012. 188:404-16.

Williams KL, Wahala WMPB, Orozco S, de Silva AM, Harris E. Antibodies targeting dengue virus envelope domain III are not required for serotype-specific protection or prevention of enhancement in vivo. Virology. 2012. 429: 12-20.

Carmona AM, Orozco S, Friebe P, Payne A, Kramer L, Harris E. A novel coding-region RNA element modulates infectious dengue virus particle production in both mammalian and mosquito cells. Virology. 2012. Jul 25. [Epub ahead of print]

Parameswaran P, Charlebois P, Tellez Y, Nunez A, Ryan EM, Malboeuf CM, Levin JZ, Lennon N, Balmaseda A, Harris E.*, Henn M.R.* Characterizing intra-host diversity of dengue virus populations and host immune effector repertoires in human dengue virus infections. J. Virol. 2012. 86:8546.

OhAinle M, Balmaseda A, Macalalad AR, Tellez Y, Zody MC, Saborío S, NuñezA, Lennon NJ, Birren BW, Gordon A, Henn MR, Harris E. Dynamics of dengue disease severity determined by the interplay between viral genetics and serotype-specific immunity. Science Transl Med. 2011. 3:114ra128.

Peña J, Harris, E. Dengue virus modulates the unfolded protein response in a time-dependent manner. 2011. J. Biol. Chem. 286:14226-36.

Friebe P, Harris E. The downstream of AUG region (DAR) element is required for mosquito-borne flavivirus RNA replication. J. Virol. 2011. 85:1900-5.

Gordon A, Saborio S, Videa E, López R, Kuan G, Balmaseda A, Harris E. Attack rate and clinical presentation of H1N1pdm compared to seasonal influenza A and B in a pediatric cohort in Nicaragua. Clin Infect Dis. 2010. 50:1462-7.

Mercado JC, Reyes M, Standish K, Kuan G, Matute JC, Ortega O, Moraga B, Avilés W, Balmaseda A, Harris E. Index cluster study of dengue virus infection in Nicaragua. Am J Trop Med Hyg. 2010. 83:683-9.

Balsitis S*, Williams K*, Lachica R, Flores D, Kyle JL, Mehlhop E, Johnson S, Diamond M, Beatty PR, Harris E. Lethal antibody enhancement of dengue disease in mice is prevented by Fc modification. PLoS Path. 2010. 6 :e1000790.

Gutierrez G, Standish K, Narvaez F, Perez MA, Elizondo D, Ortega O, Nuñez A, Kuan G, Balmaseda A, Harris E. Unusual dengue virus 3 epidemic in Nicaragua, 2009. PLoS Negl Trop Dis. 2011. 5:1394.

Other Interests

Last Updated: August 8, 2012

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