Lisa Barcellos, Ph.D.Assistant Professor of Epidemiology
PHONE: (510) 642-7814
FAX: (510) 642-5163
LOCATION: 106 Haviland Hall
E-MAIL: barcello@genepi.berkeley.edu
Research Interests
- Genetic Epidemiology -Genetic variation in the major histocompatibility complex (MHC) and autoimmune disease
- Application of statistical methods to identify gene-gene and gene-environment interactions
- Maternal-child histocompatibility and risk for autoimmune disease
- Environmental risk factors and biomarkers for susceptibility and exposure in autoimmune disease
Selected Publications
Barcellos LF, Kamdar B, Ramsay PP, DeLoa C, Lincoln R, Caillier S, Schmidt S, Haines JL, Pericak-Vance MA, Oksenberg JR, Hauser SL (2006). Clustering of autoimmune diseases in high risk for multiple sclerosis families. The Lancet Neurology 5:924-931.
Barcellos LF, Sawcer S, Ramsay PP, Baranzini SE, Thomson G, Briggs F, Cree BCA, Begovich AB, Villoslada P, Montalban X, Ucelli A, Savettieri G, Lincoln RR, DeLoa C, Haines JL, Pericak-Vance, MA, Compston A, Hauser SL, Oksenberg JR (2006). Heterogeneity at the HLA-DRB1 locus and risk for multiple sclerosis. Human Molecular Genetics 15:2813-2824.
Burwick RM, Ramsay PP, Haines JL, Hauser SL, Oksenberg JR, Pericak-Vance MA, Schmidt S, Compston A, Sawcer S, Cittadella R, Savettieri G, Quattrone A, Polman CH, Uitdehaag BMJ, Zwemmer JNP, Hawkins CP, Ollier WER, Weatherby S, Enzinger C, Fazekas F, Schmidt H, Schmidt R, Hillert J, Masterman T, Hogh P, Niino M, Kikuchi S, Maciel P, Santos M, Rio ME, Kwiecinski H, Zakrzewska-Pniewska B, Evangelou N, Palace J, Barcellos LF (2006). APOE epsilon variation in multiple sclerosis susceptibility and disease severity: some answers. Neurology 66:1373-1383.
Traherne JA, Barcellos LF*, Sawcer SJ, Compston A, Ramsay PP, Hauser SL, Oksenberg JR, Trowsdale J (2006). Association of the truncating splice site mutation in BTNL2 with multiple sclerosis is secondary to HLA-DRB1*15. Human Molecular Genetics 15:155-161. *Co-first author.
Sawcer S, Ban M, Maranian M, Yeo TW, Compston A, Kirby A, Daly MJ, De Jager PL, Walsh E, Lander ES, Rioux JD, Hafler DA, Ivinson A, Rimmler J, Gregory SG, Schmidt S, Pericak-Vance MA, Akesson E, Hillert J, Datta P, Oturai A, Ryder LP, Harbo HF, Spurkland A, Myhr KM, Laaksonen M, Booth D, Heard R, Stewart G, Lincoln R, Barcellos LF, Hauser SL, Oksenberg JR, Kenealy SJ, Haines JL (2005). International Multiple Sclerosis Genetics Consortium. A high-density screen for linkage in multiple sclerosis. American Journal of Human Genetics 77:454-467.
Barcellos LF, Begovich AB, Reynolds RL, Caillier SJ, Brassat D, Schmidt S, Grams SE, Walker K, Steiner LL, Cree BA, Stillman A, Lincoln RR, Pericak-Vance MA, Haines JL, Erlich HA, Hauser SL, Oksenberg JR (2004). Evidence for linkage and association to NOS2A in multiple sclerosis. Annals of Neurology 6:793-800.
Oksenberg JR, Barcellos LF, Cree BAC, Baranzini SE, Bugawan TL, Khan O, Lincoln RR, Swerdlin A, Mignot E, Lin L, Goodin D, Erlich HA, Schmidt S, Thomson G, Reich DE, Pericak-Vance MA, Haines JL, Hauser SL (2004). Mapping multiple sclerosis susceptibility to the HLA-DR locus in African Americans. American Journal of Human Genetics 74:160-167.
Barcellos LF, Oksenberg JR, Begovich AB, Martin ER, Schmidt S, Vittinghoff E, Goodin DS, Pelletier D, Lincoln RR, Bucher P, Swerdlin A, Pericak-Vance MA, Haines JL, Hauser SL (2002). HLA-DR2 dose effect on susceptibility to multiple sclerosis and influence on disease course. American Journal of Human Genetics 72:710-716.
Barcellos LF, Oksenberg JR Green AJ, Bucher P, Rimmler JB, Schmidt S, Garcia ME, Lincoln RR, Pericak-Vance MA, Haines JL, Hauser SL (2002). Genetic basis for clinical expression in multiple sclerosis. Brain 125:150-158.
Schmidt S, Barcellos LF, DeSombre K, Rimmler JB, Lincoln RR, Bucher P, Saunders AM, Lai E, Martin ER, Vance JM, Oksenberg JR, Hauser SL, Pericak-Vance MA, Haines JL; Multiple Sclerosis Genetics Group (2002). Association of polymorphisms in the apolipoprotein E region with susceptibility to and progression of multiple sclerosis. American Journal of Human Genetics 70:708-717.
Barcellos LF, Caillier S, Dragone L, Elder M, Vittinghoff E, Bucher P, Lincoln RR, Pericak-Vance MA, Haines, JL, Weiss A, Hauser SL, Oksenberg JR (2001). PTPRC (CD45) is not associated with the development of multiple sclerosis in U.S. patients. Nature Genetics 29:23-24.
Other Interests
- Adjunct researcher, Kaiser Permanente Division of Research
- Kaiser Permanente Research Program on Genes, Environment and Health
- Kaiser Permanente Autoimmune Disease Research Group
- International Multiple Sclerosis Genetics Consortium
- Institute of Medicine Anniversary Fellow
- National Multiple Sclerosis Society Epidemiology Task Force