Eva Harris PhD

Professor, Division of Infectious Diseases and Vaccinology
Director, Center for Global Public Health
Infectious Diseases and Immunity PhD Program Head
Courses: 
  • PH265: Molecular Parasitology (Fall)
  • PH260F: Infectious Disease Research in Developing Countries (Spring)
  • PH292/3: Immune Evasion in Host-Pathogen Interactions
Research Interests: 
  • Molecular virology, pathogenesis, immunology, epidemiology, clinical aspects, and control of dengue, Zika, and chikungunya
  • Epidemiology of influenza in tropical countries
  • Scientific capacity building in developing countries
Research Description: 

Dr. Harris has developed a multidisciplinary approach to study the molecular virology, pathogenesis, immunology, epidemiology, clinical aspects, and control of the mosquito-borne diseases dengue, Zika, and chikungunya. Her work investigates viral and host factors that modulate disease severity and immune correlates of protection and pathogenesis, using in vitro approaches, animal models, and research involving human populations. In vitro studies have focused on functional characterization of antibodies and B cell memory response, virus-host interactions and viral pathogenesis, viral fitness and evolution, and the mechanism of viral translation and replication. The mouse models developed by her group recapitulate many aspects of human dengue disease and immune response, including antibody-dependent enhancement of infection, and are being used to identify antibody determinants of protection, enhancement, and therapeutic efficacy. Her international work focuses on laboratory-based and epidemiological studies of dengue, Zika, chikungunya, and influenza in endemic Latin American countries, particularly in Nicaragua, where she has been working closely with the Ministry of Health for over 28 years. Long-term collaborations include clinical, biological, and immunological studies of severe disease through an 18-year pediatric hospital-based study; a 13-year pediatric cohort study of dengue, Zika, chikungunya, and influenza transmission in Managua; and a recently concluded cluster randomized controlled trial of evidence-based community-derived interventions to prevent and control arboviral diseases.

Selected Publications: 

Tabata, T., Petitt, M., Puerta-Guardo, H., Michlmayr, D., Wang, C., Fang-Hoover, J., Harris, E.* and Pereira, L.* (2016) Zika virus targets different primary human placental cells, suggesting two routes for vertical transmission. Cell Host Microbe. In press (Epub July 18, 2016) S1931-3128(16)30300-6. doi: 10.1016/j.chom.2016.07.002. *Co-corresponding authors. 

Puerta-Guardo, H., Glasner, D.R., and Harris, E. (2016) Dengue virus NS1 disrupts the endothelial glycocalyx, leading to hyperpermeability. PLoS Pathog. 12(7):e1005738.

Stettler, K., Beltramello, M, Espinosa, D… Harris, E., Lanzavecchia, A., Sallusto, F., and Corti, D. (2016) Specificity, cross-reactivity and function of antibodies elicited by Zika virus infection. Science. 10.1126/science.aaf8505

Kuan, G., Ramirez, S., Gresh, L., Ojeda, S., Melendez, M., Sanchez, N., Collado, D., Garcia, N., Mercado, J.C., Godron, A., Balmaseda, A., and Harris, E.  (2016) Seroprevalence of anti-chikungunya virus antibodies in children and adults in Managua, Nicaragua, after the first chikungunya epidemic, 2014-2015. PLoS Negl Trop Dis. 10(6):e0004773.

Waggoner, J.J., Balmaseda, A., Gresh, L., Abeynayake, J., Montoya, M., Sahoo, M.K., Wang, C., Kuan, G., Pinsky, B.A., Harris, E. (2016) Homotypic Dengue Virus Re-infections in Nicaraguan Children. J. Infect. Dis. pii: jiw099. [Epub ahead of print].

Katzelnick., L. Montoya, M,  Gresh, L, Balmaseda, A., and Harris, E. (2016) Neutralizing antibody titers against dengue virus correlate with protection from symptomatic infection in a longitudinal cohort. Proc. Natl. Acad. Sci. USA  113(3):728-33. PMC4725482

Schmid, M.A., Glasner, D.R., and Harris, E. (2016) Mosquito saliva increases endothelial permeability in the skin, immune cell migration, and dengue pathogenesis during antibody-dependent enhancement. PLoS Pathog. 12(6):e1005676

Katzelnick., L. Montoya, M,  Gresh, L, Balmaseda, A., and Harris, E. (2016) Neutralizing antibody titers against dengue virus correlate with protection from symptomatic infection in a longitudinal cohort. Proc. Natl. Acad. Sci. USA  113(3):728-33. PMC4725482

Beatty, P.R., Puerta Guardo, H., Killingbeck, S., Glasner, D., Hopkins, K., and Harris, E. (2015) Dengue virus non-structural protein 1 (NS1) triggers vascular leak that can be inhibited by anti-NS1 antibodies. Sci Transl Med. 7:304ra141.

Andersson, N., Nava-Aguilera, E., Arostegui, J., Morales-Perez, A., Suazo-Laguna, H., Legorreta-Soberanis, J., Hernandez-Alvarez, C., Fernandez-Salas, I., Balmaseda, A., Cortés-Guzmán, A.J., Coloma, J., Ledogar, R.J., and Harris, E. (2015) Camino Verde (Green Way) to Dengue Prevention: a pragmatic cluster-randomised controlled trial of evidence-based community mobilisation in Nicaragua and Mexico. BMJ. 351:h3267.

Fong, H. and Harris, E. (2015) Technology, innovation, and health equity. Bull World Health Organ. 93:438-438A.

Other interests: 
  • President, Sustainable Sciences Institute
  • Director, Center for Global Public Health
  • Infectious Diseases and Immunity Graduate Group
  • Microbial Biology Graduate Group
Profile Updated: August 5, 2016