Edward T. F. Wei PhD

Professor Emeritus, Toxicology
Education: 
  • PhD - University of California, San Francisco. 1969
Courses: 
  • PH 172: Introduction to Pharmacology and Toxicology (Spring)
Research Interests: 
  • Anti-inflammatory peptides
  • Drugs for melanoma and for disseminated cancer
  • Therapy for edema
  • Therapy for itching, pain and edema
Research Description: 

Dr. Wei's research is focused on the pharmacology and toxicology of peptide drugs. Four families of peptides (corticotropin-releasing factors, neurotensins, dynorphin A and mystixins) were identified to possess anti-inflammatory properties. These peptides inhibit the vascular leakage that occurs after tissue injury. The potential therapeutic values of anti-inflammatory peptides are being evaluated in animal models and in human clinical trials. The development of agents that suppress inflammation may have value in understanding mechanisms of chemical toxicity.

Current Projects: 

Recent activities are centered on finding novel therapeutic agents for the treatment of disseminated cancer. Specifically, he is looking at new anti-angiogenic agents, at melanocortin receptor antagonists, and at peptides of the corticotropin-releasing factor super family which suppress cell proliferation. He is also active in the assessment of environmental chemicals in water supplies and in evaluating their public health risk.

Selected Publications: 

Publications

Stuhr LE, Wei ET, Reed RK. Corticotropin-releasing factor reduces tumor volume, halts further growth, and enhances the effect of chemotherapy in 4T1 mammary carcinoma in mice. Tumour Biol. 2014 Feb;35(2):1365-70.

Rousseau K, Kauser S, Pritchard LE, Warhurst A, Oliver RL, Slominski A, Wei ET, Thody AJ, Tobin DJ, White A. Proopiomelanocortin (POMC), the ACTH/melanocortin precursor, is secreted by human epidermal keratinocytes and melanocytes and stimulates melanogenesis. FASEB J. 2007 Jun;21(8):1844-56.

Kauser S, Slominski A, Wei ET, Tobin DJ. Modulation of the human hair follicle pigmentary unit by corticotropin-releasing hormone and urocortin peptides. FASEB J. 2006 May;20(7):882-95.

Biró T, Ko MC, Bromm B, Wei ET, Bigliardi P, Siebenhaar F, Hashizume H, Misery L, Bergasa NV, Kamei C, Schouenborg J, Roostermann D, Szabó T, Maurer M, Bigliardi-Qi M, Meingassner JG, Hossen MA, Schmelz M, Steinhoff M. How best to fight that nasty itch - from new insights into the neuroimmunological, neuroendocrine, and neurophysiological bases of pruritus to novel therapeutic approaches. Exp Dermatol. 2005 Mar;14(3):225-40. Erratum in: Exp Dermatol. 2005. Jun;14:478-9.

Zbytek B., Slominski M., Wortsman J., Wei E.T., Mysliwska J., Slominski A. Corticotropin-releasing hormone triggers differentiation in HaCaT keratinocytes. British J Dermatol. 152:474-80, 2005.

Stair S, Carlson KW, Shuster S, Wei ET, Stern R. Mystixin peptides reduce hyaluronan deposition and edema formation. Eur J Pharmacol. 2002 Aug 30;450(3):291-6.

Patents

(R)-(-)-1,2-propanediol compositions and methods, U.S. Patent 8,529,915

N-alkylcarbonyl-amino acid ester compounds and their use for cough and pharyngitis,  U.S. Patent 8,476,317

[((1R,2S,5R)-2-isopropyl-5-methyl-cyclohexanecarbonyl)-amino]-acetic acid isopropyl ester and related compounds and their use in therapy, U.S. Patent 8,426,463

N alkylcarbonyl amino lactone compounds and their use, U.S Patent 8,258,320

Aryl-substituted derivatives of cycloalkyl and branched chain alkyl carboxylic acids useful as antinociceptive drugs for peripheral targets, U.S. Patent 7,417,048

Corticotropin-releasing hormone analogs and their uses, U.S. Patent 7,285,534

Radioligands for the TRPM8 receptor and methods therewith, U.S. Patent 7,169,377

Inhibition of abnormal cell growth with corticotropin-releasing hormone analogs, U.S. Patent 6,803,359

Compositions for the TRP-M8 binding and radioreceptor methods therewith, U.S. Patent 6,893,626

Melanocortin receptor antagonists and modulations of melanocortin receptor activity, U.S. Patent 6,228,840 and 6,953,779

Corticotropin-releasing hormone analogs, U.S. Patent 6,849,600

Presentations

"Ax-8: topical cooling/sensory TRPM8 agonist for cough," 9th International Symposium on Cough, London, UK, June 26-28, 2014

"Cooling Agents for Sensory Discomfort," BIT-Congresss on Medichem, Haikou, Hainan Island, China, Nov. 14-16, 2013 

"Design of Topical Sensory/Cooling TRPM8 Agonists for Cough," 1st International Cough Conference, GuangZhou, China, Nov. 10-11, 2013

"Design of Topical Sensory Agonists for Cough," 7th International Symposium on Cough, London, UK, July 5-8, 2012

6th International Symposium for Study of Cell/Tissue Injury and Cytoprotection/Organ Protection, St. Petersburg, Russia, Oct. 12-14, 2011

"Design of Topical Cooling Agents for Itch," 6th International Workshop for the Study of Itch, Brest, France, Sept. 4–6, 2011

Profile Updated: September 3, 2014